Dr. Regina Mangieri published a research article entitled "Effect of Chronic Intermittent Ethanol Vapor Exposure on RNA Content of Brain- Derived Extracellular Vesicles" in the journal Alcohol.
This research investigated how chronic ethanol exposure impacts RNA transcripts contained in extracellular vesicles (EV), and the functional outcomes of these changes. The results indicated that alcohol exposure significantly alters EV content in a manner that contributes to many of the negative consequences associated with alcohol use disorder, (AUD) such as increases in neuroinflammation, changes in synaptic transmission, and cell death. Results from this and future studies will contribute to our knowledge regarding the perpetuation of AUD and associated consequences, such as synaptic organizational changes and may lead to us to uncover new therapeutic targets for the treatment of this disorder.
Baratta A.M., Mangieri R.A., Aziz H.C., Lopez M.F., Farris S.P. & Homanics G.E., Effect of Chronic Intermittent Ethanol Vapor Exposure on RNA Content of Brain-Derived Extracellular Vesicles, Alcohol (2022), doi: https://doi.org/10.1016/j.alcohol.2022.08.006.