Molecular mechanisms that underlie addiction, anxiety, and pain; treatment development.
Molecular actions of drugs of abuse on brain signaling systems; genetics of alcohol susceptibility.
Molecular mechanisms of ion channel function and their role in electrical signaling.
Development of mutant mice to test genetic, environmental causes of excessive alcohol consumption.
Genetic and environmental regulation of cellular behaviors that govern craniofacial development.
Therapeutic and diagnostic applications of aptamers; protein and metabolic engineering.
Addictive behaviors; risk-taking; alcohol abuse; cognitive processes in clinical psychopathology.
Genomics; genome-wide transcriptional programs and mechanisms; microarray technology.
Synaptic integration and plasticity; cellular actions of learning and memory; epileptogenesis.
Plasticity of nerual structure; synaptic connectivity and glial-neuronal interactions following brain damage and during learning.
Effects of ethanol and similar drugs on NMDA-stimulated ion channels and voltage-dependent calcium channels.
Neural systems related to risk, onset and early disease progression in affective and substance use disorders.
Molecular and cellular mechanisms involved in the psychoactive and addictive properties of drugs of abuse.
Role of mitochondria in intracellular communication, disease processes, and toxic actions of chemicals.
Amino acid-derived neurotransmitter systems; synaptic transmission, expression of alcohol-related disorders.
Genetic mechanisms that govern behavior and contribute to neurological disorders.
Mechanisms of alcohol actions using behavioral genetics, functional genomics and cellular neuroscience.